Sequential intra-articular HCAd-NFκB-IL-1Ra delivery improves therapeutic efficacy in post-traumatic osteoarthritis
Jiansen Yan, Zelong Dou, Camilla F. Majano, Racel Cela, Ming‐Ming Jiang, Syed Shayan Mehdi, Joud Al Azaat, Duncan Crosby, Amanda Rosewell Shaw, Lisa A. Yuva‐Paylor, Surabi Veeraragavan, Oscar Ruiz, Donna J. Palmer, Philip Ng, Nele A.T Haelterman, , Brendan Lee
This study shows that switching adenovirus serotypes for repeated gene therapy in osteoarthritis improves cartilage preservation but not functional outcomes.
bioRxiv · Jul 28, 2026 · PreprintMolecular Biology