Nele A.T Haelterman

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

This study shows that switching adenovirus serotypes for repeated gene therapy in osteoarthritis improves cartilage preservation but not functional outcomes.

This study identifies validated genetic and tracer tools to map knee-innervating neurons, aiding in understanding joint pain mechanisms.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

The paper introduces KneEZ Clear, an aqueous-based tissue clearing method for musculoskeletal tissues that preserves fluorescence and avoids equipment requirements.

This study optimizes tissue clearing and imaging methods to achieve high-resolution 3D visualization of the vasculature in adult murine knee tissues.

The paper functionally tests ASD missense variants in Drosophila, finding 38% caused functional alterations and identifying GLRA2 as a cause of neurodevelopmental phenotypes.

This study examines tendon and motor phenotypes in Crtap-/- mice, finding thinner tendons, altered collagen structure, and motor impairments linked to tendon/ligament dysfunction in OI.