Surabi Veeraragavan

The paper identifies a druggable CSNK2A1-MeCP2 regulatory axis linking Okur-Chung neurodevelopmental syndrome with MECP2-related disorders through CRISPR screens and mouse models.

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

This study shows that switching adenovirus serotypes for repeated gene therapy in osteoarthritis improves cartilage preservation but not functional outcomes.

The paper shows that different isoforms of CIC interact with paralogs ATXN1 and ATXN1L, leading to distinct phenotypes and explaining tissue-specific vulnerability in neurological diseases.

This study shows that KRAS mutations drive brain arteriovenous malformations (bAVMs) in specific brain regions and that MEK inhibition can reduce their severity in mice, suggesting a potential therapeutic approach for human bAVMs.

This study generates and characterizes a rat model with a truncating Magel2 mutation, revealing altered behavioral and physiological traits consistent with human neurodevelopmental disorders.

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.