Zelong Dou

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

This study shows that switching adenovirus serotypes for repeated gene therapy in osteoarthritis improves cartilage preservation but not functional outcomes.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study transplants rat perichondrium into cartilage defects, showing it forms hyaline cartilage that integrates with subchondral bone and persists over time.