Cancer BiologybioRxivPreprint
L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas.
Aussel Anaïs, Ivan Nemazanyy, Ashaina Vandenberghe…·Johanna Chiche
This study shows that L-asparaginase treatment induces metabolic plasticity in B-cell lymphomas, making them vulnerable to PARP1/2 inhibitor Olaparib, with potential broader therapeutic applications.
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