L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas.
Aussel Anaïs, Ivan Nemazanyy, Ashaina Vandenberghe, Pauline Meola, Dorat Noémie, Rachel Paul, Lama Habbouche, Laurie Exposito, Nicolas Nottet, Virginie Pétrilli, Edmond Chiche, Nicolas Mounier, Sandrine Marchetti, Cédric Chaveroux, Jean‐Ehrland Ricci, Johanna Chiche
This study shows that L-asparaginase treatment induces metabolic plasticity in B-cell lymphomas, making them vulnerable to PARP1/2 inhibitor Olaparib, with potential broader therapeutic applications.
bioRxiv · Oct 24, 2025 · PreprintCancer Biology