Author

Johanna Chiche

InsermORCID 0000-0001-5276-1125Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

Adèle RivaultiD· 1 shared Arnaud JacqueliD· 1 shared Ashaina VandenbergheiD· 1 shared Aussel Anaïs· 1 shared Cécile Favreau· 1 shared Cédric ChaverouxiD· 1 shared Chloe Delaby· 1 shared Dorat Noémie· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Adèle RivaultORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 24, 2025

L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas.

Aussel Anaïs, Ivan Nemazanyy, Ashaina Vandenberghe…·Johanna Chiche

This study shows that L-asparaginase treatment induces metabolic plasticity in B-cell lymphomas, making them vulnerable to PARP1/2 inhibitor Olaparib, with potential broader therapeutic applications.

1 citation

humanmetabolomics

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ImmunologybioRxivPreprintAug 22, 2025

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization

Emeline Kerreneur, Paul Chaintreuil, Chloe Delaby…·Arnaud Jacquel

This study identifies cathepsin B as a novel upstream activator of non-apoptotic caspase-8, driving anti-inflammatory macrophage polarization and differentiation.

DOI 10.1101/2025.08.22.671722

humanexperimental assay

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