Ivan Nemazanyy

This study identifies PTH1R signaling in AgRP neurons as a mechanism controlling feeding behavior and nutrient partitioning through distinct kinase activation and lipophagic processes.

This study shows that bone-derived hormone osteocalcin regulates locomotion by maintaining mitochondrial function in spinal motoneurons, and that this effect can be reversed in aged mice.

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

This study shows that timing DHODH inhibition during dawn reduces obesity in male mice by improving mitochondrial function and metabolic rhythms.

This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.

This study shows that L-asparaginase treatment induces metabolic plasticity in B-cell lymphomas, making them vulnerable to PARP1/2 inhibitor Olaparib, with potential broader therapeutic applications.

This study shows that structured alignment of cardiomyocytes improves mitochondrial function and bioenergetic efficiency, highlighting the role of cellular organization in heart health.

This study shows that the G-quadruplex ligand RHPS4 reduces radioresistance by inhibiting mitochondrial adaptations caused by ionising irradiation.

The paper identifies NAD+ availability and redox state as constraints on developmental speed in Drosophila eye differentiation.

This study identifies m3C as a novel mitochondrial mRNA modification catalyzed by METTL8, which promotes tumor progression by enhancing complex I activity and oncogenic pathways.

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.