Autoreactive IgG levels and Fc receptor γ subunit upregulation drive mechanical allodynia after nerve constriction or crush injury
Nathan T. Fiore, Kendal F. Willcox, Anamaria R Grieco, Dorsa Dayani, Younus A. Zuberi, Cobi J. Heijnen, Peter M. Grace
This study shows that B cell-derived autoreactive IgG and FcγR upregulation drive mechanical allodynia after nerve constriction or crush injury, but not after nerve transection.
bioRxiv · Mar 22, 2025 · PreprintNeuroscience