Nathan T. Fiore

DRG meningeal tertiary lymphoid structures are regulated by B cells as a pronociceptive locus after peripheral nerve injury

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer

This study shows that colorectal cancer in mice and rhesus macaques causes inflammatory neuropathy with calcium dysregulation and myelin issues, suggesting a causal link to chronic neurological problems in cancer survivors.

Autoreactive IgG levels and Fc receptor γ subunit upregulation drive mechanical allodynia after nerve constriction or crush injury

This study shows that B cell-derived autoreactive IgG and FcγR upregulation drive mechanical allodynia after nerve constriction or crush injury, but not after nerve transection.

Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury

This study identifies sex-specific transcriptomic changes in spinal microglia following nerve injury, showing distinct gene expression patterns between males and females.