Peter M. Grace

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

This study shows that colorectal cancer in mice and rhesus macaques causes inflammatory neuropathy with calcium dysregulation and myelin issues, suggesting a causal link to chronic neurological problems in cancer survivors.

This study shows that inhibiting F1 ATP synthase with EB2023 causes transient mitochondrial stress in AML cells, enabling effective treatment without harming healthy tissues.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

This study shows that B cell-derived autoreactive IgG and FcγR upregulation drive mechanical allodynia after nerve constriction or crush injury, but not after nerve transection.

This paper shows that diroximel fumarate (DRF) reduces MGO-induced pain hypersensitivity in mice by activating Nrf2 and decreasing ISR activation in DRG neurons.

This study shows that Nrf2 activators reverse doxorubicin-induced cognitive and motor impairments and brain structural changes in mice.

This study shows that voluntary wheel running before sciatic nerve injury reduces neuropathic pain in rats by enhancing antioxidant defenses through Nrf2 signaling.