eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer
Jacob A. Boyer, Ezra Y. Rosen, Malvika Sharma, Madeline A. Dorso, Nicholas Mai, Corina Amor, Jason Reiter, Ram Kannan, Sunyana Gadal, Jianing Xu, Matthew M. Miele, Zhuoning Li, Xiaoping Chen, Qing Chang, Fresia G. Pareja, , Neal X. Rosen
This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.
Proceedings of the National Academy of Sciences · Jul 21, 2025Peer-reviewedCancer Biology