Malvika Sharma

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

The paper shows that diet-induced insulin resistance results from increased PTEN expression, which inhibits PI3K signaling, and that PTEN and mTORC1 inhibitors can reverse this effect.