Corina Amor

CAR T cell targeting of inflammatory myeloid progenitors in the bone marrow remodels border-associated macrophages and reverses cognitive aging

This study shows that targeting inflammatory myeloid progenitors in the bone marrow with CAR T cells reduces neuroinflammation and cognitive decline in aging and Alzheimer's models.

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.

A brain-body feedback loop driving HPA-axis dysfunction in breast cancer

This study shows that breast cancer disrupts hypothalamic GC rhythms by altering PVNCRH neuron activity, and that targeting these neurons can reduce tumor progression.

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.