Jacob A. Boyer

This study investigates the metabolism of epigenetic ribonucleosides in human cells, revealing cytotoxic effects and mechanisms of RNA misincorporation and nucleolar stress.

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.