Site-specific replacement of large-scale DNA fragments in human cells
Hojun Jung, Bada Jeong, Yong-Woo Kim, Chanju Jung, Seoho Lee, Heesoo Uhm, Hyoungrak Kim, Ye Eun Oh, Y.H. Park, Yeji Lee, 강미승, Hyeon Woo Im, Doyoon Kim, Soyoon Lee, Yohan Kim, , Sangsu Bae
This paper introduces a gene replacement tool called Prime Assembly (PA) that efficiently and accurately replaces large DNA fragments in human cells, restoring gene function in disease-related genes.
Nature Biotechnology · Aug 28, 2026Peer-reviewedMolecular Biology