Treatment of murine autoimmune myocarditis with a novel monoclonal antibody that targets multiple inflammatory pathways
Stefano A Toldo, Dror Luger, Aimee E. Vozenilek, Antonio Abbate, Jazmin Kelly, Eleonora Mezzaroma, Cyndya A. Shibao, Marwa A Abd-ElDayem, Paul Klenerman, Ron Waksman, Renu Virmani, Jennifer A. Maynard, David G. Harrison, Moshe Y. Flugelman, Stephen E. Epstein
This paper demonstrates that targeting CD160+ cells with a monoclonal antibody prevents autoimmune-induced myocarditis by depleting NK cells and other cytotoxic T cells, inhibiting multiple inflammatory pathways.
bioRxiv · Mar 31, 2026 · PreprintSystems Biology