Jennifer A. Maynard

Broad Sarbecovirus Neutralization by an S2-Directed Plasma Antibody Defines a New Site of Vulnerability in SARS-like Viruses

The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.

Mouse Fc-FcγRIV structure guides Fc engineering for cross-species FcγR recognition

This paper determines the structure of mouse FcγRIV and uses it to engineer a human Fc variant that enhances cross-species FcγR recognition.

Antibodies blocking PlGF or VEGF interactions with the NRP1 receptormediate anti-proliferative effects

The paper identifies antibodies that block PlGF or VEGFA interactions with NRP1, showing anti-proliferative effects in cancer cells and reduced angiogenesis.

Treatment of murine autoimmune myocarditis with a novel monoclonal antibody that targets multiple inflammatory pathways

This paper demonstrates that targeting CD160+ cells with a monoclonal antibody prevents autoimmune-induced myocarditis by depleting NK cells and other cytotoxic T cells, inhibiting multiple inflammatory pathways.

Selective decoupling of IgG1 binding to viral Fc receptorsrestores antibody-mediated NK cell activation against HCMV-infected cells

This paper engineers IgG1 antibodies with modified Fc domains to resist viral Fc receptor binding, enhancing NK cell activation and reducing HCMV spread in infected cells.

Structural Basis for Antibody Neutralization of Pertussis Toxin

This paper defines neutralizing epitopes on pertussis toxin using cryo-EM structures and functional assays, providing insights for vaccine development.

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.