Renu Virmani

This study shows that GIMAP6 loss leads to inflammatory vasculopathy and atherosclerosis, causing heart failure and early death, and identifies GIMAP6 as a protective factor against cardiovascular disease.

This paper demonstrates that targeting CD160+ cells with a monoclonal antibody prevents autoimmune-induced myocarditis by depleting NK cells and other cytotoxic T cells, inhibiting multiple inflammatory pathways.

This study shows that a polygenic risk score for coronary artery disease is associated with more severe atherosclerosis features in autopsy samples of sudden death cases.

This study examines the association between pathogenic or likely pathogenic genetic variants in cardiomyopathy and arrhythmia genes and unexplained sudden cardiac death in adults with no gross pathological findings.

This study evaluates the genetic architecture of sudden cardiac arrest through GWAS and Mendelian randomization, finding genetic correlations with CAD, height, BMI, and electrical instability traits.