Azithromycin Derivatives to Mitigate Off-Target Inhibition of Autophagy and Retain Beneficial Host Directed Effects
Duc Q Doan, Shawn WH Liu, Samuel Clark, Sylvia A. Sapula, Thomas Crowhurst, Paul N. Reynolds, Benjamin T. Kopp, Anton Blencowe, Eugene Roscioli
This study develops AZM derivatives that maintain anti-inflammatory effects while allowing autophagy, reducing resistance risk.
bioRxiv · Sep 2, 2026 · PreprintCell Biology