Eugene Roscioli

This study develops AZM derivatives that maintain anti-inflammatory effects while allowing autophagy, reducing resistance risk.

The paper shows that autophagy is suppressed in peripheral blood mononuclear cells of COPD patients, as indicated by reduced autophagic flux and fewer autophagy-related vacuoles.

This study compares the effects of perfluorocarbon exposure on submerged and air-liquid interface airway models, finding that the organotypic ALI model better predicts in vivo responses.

This paper shows azithromycin inhibits autophagy and presents a modified version, AZM-[O], that reduces this effect while retaining antimicrobial and immunomodulatory functions.