Author

Sylvia A. Sapula

Adelaide UniversityORCID 0000-0002-5534-9774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Anton BlencoweiD· 2 shared Benjamin T. KoppiD· 2 shared Eugene RoscioliiD· 2 shared Duc Q Doan· 1 shared Hanbiao Chen· 1 shared Henrietta VenteriD· 1 shared Hubertus P. A. JersmanniD· 1 shared John D. TurnidgeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Anton BlencoweORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Azithromycin Derivatives to Mitigate Off-Target Inhibition of Autophagy and Retain Beneficial Host Directed Effects

Duc Q Doan, Shawn WH Liu, Samuel Clark, Sylvia A. Sapula, Thomas Crowhurst, Paul N. Reynolds, Benjamin T. Kopp, Anton Blencowe, Eugene Roscioli

This study develops AZM derivatives that maintain anti-inflammatory effects while allowing autophagy, reducing resistance risk.

bioRxiv · Sep 2, 2026 · PreprintCell Biology

Commonly used non-antibiotic medications promote mutation frequency and antimicrobial resistance in Escherichia coli

Hanbiao Chen, Sylvia A. Sapula, John D. Turnidge, Henrietta Venter

This study shows that non-antibiotic medications increase mutation frequency and antimicrobial resistance in E. coli, particularly when combined.

bioRxiv · Jan 13, 2025 · PreprintMicrobiology

Modifying Azithromycin to Mitigate Arrested Autophagy

Ryan D. Quarrington, Shiye Chen, Sylvia A. Sapula, Shawn W H Liu, Susan Elizabeth Lester, Matthew M Miller, Vesna Munić Kos, Benjamin T. Kopp, Hubertus P. A. Jersmann, Anton Blencowe, Eugene Roscioli

This paper shows azithromycin inhibits autophagy and presents a modified version, AZM-[O], that reduces this effect while retaining antimicrobial and immunomodulatory functions.

bioRxiv · Apr 25, 2024 · PreprintBiochemistry