ImmunologybioRxivPreprint
Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody
Vishal Rao, Iden A. Sapse, Hallie Cohn…·Camila H. Coelho
The paper identifies clonotype-enriched mutations in the light chain of a public antibody that enhance affinity for a conserved viral epitope and increase after repeated vaccinations.