Evolution of a genome-architecture-encoded gene regulation system in trypanosomatids
Saurav Mallik, Meir Sylman, Moshe Kafri, Maayan Yoles, Bar Cohen, Dvir Dahary, Orna Dahan, Gerald Frank Späth, Shulamit Michaeli, Yitzhak Pilpel
This study investigates the evolution of gene regulation in trypanosomatids, showing a shift from gene-specific regulation to architecture-encoded regulation through polycistronic transcription units.
bioRxiv · Jul 31, 2026 · PreprintEvolutionary Biology