Saurav Mallik

This study investigates the evolution of gene regulation in trypanosomatids, showing a shift from gene-specific regulation to architecture-encoded regulation through polycistronic transcription units.

This study investigates the evolutionary origins of host association and polycistronic transcription in trypanosomatids using comparative genomics across 47 genomes.

The paper identifies co-translational assembly as a mechanism promoting homomerization of paralogs, which enhances their functional divergence.

The paper identifies structural determinants of co-translational protein complex assembly and shows how intertwined subunits require synchronized proteostasis, with implications for protein stability and mRNA localization.

The paper shows that mutational biases can lead to the neutral evolution of heteromeric protein complexes over homomeric ones after gene duplication.

The paper identifies conserved molecular principles governing mRNA half-life regulation through structural features and evolutionary analysis.

The paper identifies native topology and cooperative stability as key factors regulating protein half-life, showing how structural features and complex interactions influence degradation rates across diverse proteins.