Shulamit Michaeli

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

This study investigates the evolution of gene regulation in trypanosomatids, showing a shift from gene-specific regulation to architecture-encoded regulation through polycistronic transcription units.

This study investigates the evolutionary origins of host association and polycistronic transcription in trypanosomatids using comparative genomics across 47 genomes.

The paper shows genome instability in Leishmania enables fitness gain through epistatic gene copy number variations and compensatory post-transcriptional mechanisms.

The paper shows that the SLS pathway in Trypanosoma brucei is triggered by disruptions in ER, Golgi, or mitochondrial protein handling and identifies PK3 phosphorylation as critical for its activation.