Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy
Madeline R. Spetz, Hyosung Kim, Alexander P Ligocki, Swathi R Shekharan, Hannah J. Brien, Daniel Chavarría, Dylan J Conger, Rebecca L. Shattuck-Brandt, Alena Shostak, Rebecca Embalabala, Matthew Schrag, Ethan S. Lippmann, Jonathan M. Brunger
This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.
bioRxiv · Mar 12, 2025 · PreprintBioengineering