Author

Hannah J. Brien

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Jonathan M. BrungeriD· 2 shared Alena Shostak· 1 shared Alexander P LigockiiD· 1 shared Daniel ChavarríaiD· 1 shared Dylan J Conger· 1 shared Ethan S. LippmanniD· 1 shared Hyosung KimiD· 1 shared Jhanvi SharmaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

Jonathan M. BrungerORCID

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2 papers

Recent·Most cited

Encoded cell-material interactions to reroute cytokine signaling for regenerative medicine

Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger

The paper introduces nMATRIX, a material-cell platform that converts inflammatory cytokine signals into anti-inflammatory cues to reprogram macrophage phenotypes.

Advanced Healthcare Materials · Jul 28, 2026Peer-reviewedBioengineering

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy

Madeline R. Spetz, Hyosung Kim, Alexander P Ligocki, Swathi R Shekharan, Hannah J. Brien, Daniel Chavarría, Dylan J Conger, Rebecca L. Shattuck-Brandt, Alena Shostak, Rebecca Embalabala, Matthew Schrag, Ethan S. Lippmann, Jonathan M. Brunger

This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.

bioRxiv · Mar 12, 2025 · PreprintBioengineering