Swathi Shekharan

This study investigates how phosphorylation at specific tyrosine sites within SH2 domains affects ligand binding, finding that phosphorylation at Y63 in PTPN11 reduces binding of physiologically relevant substrates.

This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.

The paper introduces a synthetic toolkit for efficiently producing tyrosine phosphorylated proteins by leveraging signaling-inspired targeting interactions.