Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
Ryan H. Purcell, Esra Sefik, Erica Werner, Alexia Tyler King, Trenell J. Mosley, Megan E. Merritt-Garza, Pankaj Chopra, Zachary T. McEachin, Sridhar Karne, Nisha Raj, Brandon J. Vaglio, Dylan Sullivan, Bonnie L. Firestein, Kedamawit Tilahun, Maxine I. Robinette, , Jennifer Gladys Mulle
This study uses cross-species scRNA-seq to show that the 3q29 deletion causes mitochondrial dysfunction in both human cortical organoids and mouse models, suggesting a conserved metabolic disruption in schizophrenia.
Science Advances · Aug 16, 2023Peer-reviewedGenomics