GenomicsScience AdvancesPeer-reviewed
Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
Ryan H. Purcell, Esra Sefik, Erica Werner…·Jennifer Gladys Mulle
This study uses cross-species scRNA-seq to show that the 3q29 deletion causes mitochondrial dysfunction in both human cortical organoids and mouse models, suggesting a conserved metabolic disruption in schizophrenia.