Alexia Tyler King

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signatures

This study develops human spinal cord organoids and assembloids to model oligodendrocyte development and disease states, showing they recapitulate developmental signatures and cytokine-induced dysfunction seen in multiple sclerosis.

Temporal regulation of human reactive astrocytes reveals their capacity for antigen presentation

This study shows human astrocytes can present antigens via MHCII after chronic cytokine exposure, revealing their potential as antigen-presenting cells.

Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion

This study uses human brain organoids to show that glioblastoma cells adopt neuron-like states and interact with region-specific synaptic inputs to drive invasion.

Lead (Pb) exposure alters neural cell fate in the developing human brain

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

Sensory neurostimulation promotes stress resilience with frequency-specificity

This study shows that AV flicker at specific frequencies can mitigate stress-induced changes in mice, with 10Hz effective in males and 40Hz in females.

ALG13 loss-of-function alters glycosylation, impairs neuronal maturation, and drives network hypoactivity in a cortical organoid model of CDG

This study uses cortical organoids to show that ALG13 loss-of-function causes glycosylation defects, neuronal maturation issues, and network hypoactivity in CDG.

Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion

This study uses cross-species scRNA-seq to show that the 3q29 deletion causes mitochondrial dysfunction in both human cortical organoids and mouse models, suggesting a conserved metabolic disruption in schizophrenia.