PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer
T. H. Truong, E. A. Benner, K. M. Hagen, N. A. Temiz, C. Perez Kerkvliet, Y. Wang, E. Cortes-Sanchez, C.-H. Yang, T. Pengo, K. P. Guillen, B. W. Welm, S. Telang, C. A. Lange, J. H. Ostrander
This study identifies PELP1/SRC-3-dependent regulation of metabolic kinases as a driver of therapy-resistant ER+ breast cancer and shows that targeting PFKFBs can block tumorsphere formation in resistant models.
bioRxiv · Aug 7, 2020Cancer Biology