N. A. Temiz

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases

This study shows that human APOBEC3B causes tumor heterogeneity and metastases in mice, with increased C-to-T mutations and structural variations.

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer

This study identifies PELP1/SRC-3-dependent regulation of metabolic kinases as a driver of therapy-resistant ER+ breast cancer and shows that targeting PFKFBs can block tumorsphere formation in resistant models.