CRISPR-targeted display of functional T cell receptors enables engineering of enhanced specificity and prediction of cross-reactivity
R. Vazquez-Lombardi, J. Jung, F. Bieberich, E. Kapetanovic, E. Aznauryan, C. R. Weber, S. T. Reddy
The paper introduces a CRISPR-based platform to engineer TCRs with enhanced specificity and predict cross-reactivity by profiling mutational landscapes and screening TCR libraries.
bioRxiv · Jun 23, 2020 · PreprintImmunology