The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 on Intracellular Trafficking, Autophagy, and Apoptosis
E. B. Stephens, W. Henke, M. Kalamvoki
This study investigates how tyrosine-based sorting signals in the ORF3a protein of SARS-CoV-2 affect intracellular trafficking, apoptosis, and autophagy, finding that multiple motifs are required for efficient transport and that surface expression is not necessary for autophagy.
bioRxiv · Jul 24, 2023 · PreprintCell Biology