Author

E. B. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

T. Ndung'u· 5 shared M. Mthembu· 4 shared Z. Mhlane· 4 shared D. Ramjit· 3 shared F. Karim· 3 shared K. Nyamande· 3 shared M. Mitha· 3 shared P. Maharaj· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

T. Ndung'u

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Author profile →

5 papers

Recent·Most cited

Dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of people living with HIV

M. Mthembu, H. Claassen, S. Khuzwayo, V. Voillet, A. Naidoo, K. Nyamande, D. F. Khan, P. Maharaj, M. Mitha, Z. Mhlane, F. Karim, E. Andersen-Nissen, T. Ndung'u, G. Pollara, E. B. Wong

This study identifies dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of HIV-positive individuals, linked to reduced IL-17A production and increased regulatory molecule expression, contributing to susceptibility to tuberculosis.

bioRxiv · May 5, 2023 · PreprintImmunology

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts.

M. Mthembu, K. A. Bowman, L. L. Davies, S. Khuzwayo, L. Mazibuko, T. Bassett, D. Ramjit, Z. Mhlane, F. Karim, G. Alter, T. Ndung'u, E. B. Wong

This study compares Mtb-specific IFN-γ and IgG responses in HIV-positive and HIV-negative individuals, finding higher IgG levels and lower QFT positivity in HIV-positive people with low CD4 counts.

bioRxiv · Oct 11, 2022 · PreprintImmunology

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection

S. Khuzwayo, M. Mthembu, E. W. Meermeier, S. M. Prakadan, S. W. Kazer, T. Bassett, K. Nyamande, D. Fakey Khan, P. Maharaj, M. Mitha, M. Suleman, Z. Mhlane, D. Ramjit, F. Khan, A. K. Shalek, , E. B. Wong

This study identifies distinct phenotypic, functional, and transcriptomic features of MR1-restricted MAIT cells in the human lung mucosa, showing their preservation in HIV infection.

bioRxiv · Nov 19, 2020Immunology

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection.

D. Muema, M. Mthembu, A. Schiff, U. Singh, C. Bjorn, T. Bassett, S. S. Rasehlo, K. Nyamande, D. F. Khan, P. Maharaj, M. Mitha, M. Suleman, Z. Mhlane, T. Naidoo, D. Ramjit, , E. B. Wong

This study compares HIV-induced gene expression in peripheral blood and bronchoalveolar cells, revealing distinct inflammatory signatures and compartment-specific effects.

bioRxiv · Oct 23, 2019Immunology

Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection

S. W. Kazer, T. P. Aicher, D. M. Muema, S. L. Carroll, J. Ordovas-Montanes, C. G. K. Ziegler, S. K. Nyquist, E. B. Wong, N. Ismail, M. Dong, A. Moodley, K. L. Dong, Z. M. Ndhlovu, T. Ndung'u, B. D. Walker, A. K. Shalek

The paper uses single-cell RNA-sequencing to study immune dynamics in HIV-1 infection, identifying key cellular responses and their temporal progression in untreated individuals.

bioRxiv · May 30, 2019 · PreprintImmunology