Author

G. Pollara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Assay:bulk RNA-seq· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

M. Noursadeghi· 6 shared C. Venturini· 4 shared G. S. Tomlinson· 3 shared J. S. Brown· 3 shared C. T. Turner· 2 shared E. C. Wall· 2 shared R. S. Heyderman· 2 shared A. Akarca· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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6 shared papersImmunology

M. Noursadeghi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

C. T. Turner, J. Rosenheim, C. Thakker, A. Chandran, H. Wilson, C. Venturini, G. Pollara, B. Chain, G. S. Tomlinson, M. Noursadeghi

The paper profiles single-cell transcriptomes and T cell receptors in human tuberculin skin tests to characterize the immune response to Mycobacterium tuberculosis.

bioRxiv · Jun 25, 2024 · PreprintImmunology

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality.

J.-A. Guerra-Assuncao, P. Chakroborty, G. Pollara, C. Venturini, V. S. Mlozowa, B. Denis, M. Nyirenda, D. G. Lalloo, M. Noursadeghi, R. S. Heyderman, J. S. Brown, E. C. Wall

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

bioRxiv · May 24, 2024 · PreprintImmunology

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

J. M. Chan, E. Ramos-Sevillano, M. Betts, H. U. Wilson, C. M. Weight, A. Houhou-Ousalah, G. Pollara, J. S. Brown, R. S. Heyderman

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

bioRxiv · Oct 18, 2023 · PreprintMicrobiology

Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection

F. R. Hammond, A. Lewis, G. Pollara, G. S. Tomlinson, M. Noursadeghi, E. Kiss-Toth, P. M. Elks

This study identifies Trib1 and Cop1 as immune regulators that protect against mycobacterial infection by modulating macrophage function and inflammation.

bioRxiv · Aug 25, 2023Immunology

Dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of people living with HIV

M. Mthembu, H. Claassen, S. Khuzwayo, V. Voillet, A. Naidoo, K. Nyamande, D. F. Khan, P. Maharaj, M. Mitha, Z. Mhlane, F. Karim, E. Andersen-Nissen, T. Ndung'u, G. Pollara, E. B. Wong

This study identifies dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of HIV-positive individuals, linked to reduced IL-17A production and increased regulatory molecule expression, contributing to susceptibility to tuberculosis.

bioRxiv · May 5, 2023 · PreprintImmunology

Exaggerated in vivo IL-17 responses discriminate recall responses in active TB

G. Pollara, C. T. Turner, G. S. Tomlinson, L. C. Bell, A. Khan, L. F. Peralta, A. Folino, A. Akarca, C. Venturini, T. Baker, F. L. Ricciardolo, T. Marafioti, C. Ugarte-Gil, D. A. Moore, B. M. Chain, M. Noursadeghi

The paper shows that exaggerated IL-17A/F responses in active TB distinguish it from cured or latent TB, suggesting therapeutic targeting of this pathway.

bioRxiv · Jul 31, 2020Immunology

Transcriptional response modules characterise IL-1β and IL-6 activity in COVID-19

L. C. K. Bell, C. Meydan, J. Kim, J. Foox, D. Butler, C. E. Mason, S. D. Shapira, M. Noursadeghi, G. Pollara

The paper identifies IL-1β and IL-6 transcriptional response modules in COVID-19 and finds they reflect cytokine bioactivity without correlating with disease severity.

bioRxiv · Jul 22, 2020Immunology

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

E. C. Wall, J. A. Guerra-Assuncao, G. Pollara, C. Venturini, V. Mlowzowa, T. Allain, D. Lalloo, M. Noursadeghi, J. S. Brown, R. Heyderman

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

bioRxiv · Dec 7, 2018 · PreprintImmunology