PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC
L.-M. Appel, V. Franke, M. Bruno, I. Grishkovskaya, A. Kasiliauskaite, U. E. Schoeberl, M. G. Puchinger, S. Kostrhon, E. Beltzung, K. Mechtler, G. Lin, A. Vlasova, M. Leeb, R. Pavri, A. Stark, , D. Slade
This study identifies PHF3 as a CTD-binding factor that regulates neuronal gene expression by inhibiting Pol II elongation and mRNA stability.
bioRxiv · Feb 11, 2020Biochemistry