Integration of prophages into CRISPR loci remodels viral immunity in Streptococcus pyogenes
A. Varble, E. Campisi, C. W. Euler, J. Fyodorova, J. Rostol, V. A. Fischetti, L. A. Marraffini
This study shows that the {Phi}AP1.1 phage uses an anti-CRISPR protein to temporarily disable CRISPR immunity, then integrates into the CRISPR locus to modulate immunity through spacer deletion and transfer.
bioRxiv · Oct 9, 2020 · PreprintMicrobiology