Author

A. Varble

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:gene regulatory network inference· 2 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. B. Janssen· 1 shared A. M. Bravo· 1 shared A. Stream· 1 shared C. W. Euler· 1 shared E. Bjanes· 1 shared E. Campisi· 1 shared J. Fyodorova· 1 shared J. L. Baker· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A. B. Janssen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

An efficient in vivo-inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies

E. Bjanes, A. Stream, A. B. Janssen, P. S. Gibson, A. M. Bravo, S. Dahesh, J. L. Baker, A. Varble, V. Nizet, J.-W. Veening

This paper develops a doxycycline-inducible CRISPRi system for GAS to enable efficient gene repression and presents a genome browser for GAS genetic features.

bioRxiv · Feb 22, 2024 · PreprintMicrobiology

Integration of prophages into CRISPR loci remodels viral immunity in Streptococcus pyogenes

A. Varble, E. Campisi, C. W. Euler, J. Fyodorova, J. Rostol, V. A. Fischetti, L. A. Marraffini

This study shows that the {Phi}AP1.1 phage uses an anti-CRISPR protein to temporarily disable CRISPR immunity, then integrates into the CRISPR locus to modulate immunity through spacer deletion and transfer.

bioRxiv · Oct 9, 2020 · PreprintMicrobiology