Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
S. S. Gomes Dias, V. S. Cardoso, A. C. Ferreira, C. Q. Sacramento, N. Fintelman-Rodrigues, J. R. Temerozo, L. Teixeira, E. A. Barreto, M. Mattos, C. S. de Freitas, I. Azevedo-Quintanilha, P. P. A. Manso, E. D. Hottz, C. R. R. Pao, D. C. Bou-Habib, , P. T. Bozza
This study shows that lipid droplets support SARS-CoV-2 replication and inflammatory mediator production, with DGAT-1 inhibition reducing viral replication and inflammation.
bioRxiv · Aug 22, 2020 · PreprintImmunology