Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells
C. W. Wasson, S. L. Dibb, B. Caballero Ruiz, E. M. Clavane, R. Wells, V. Kakkar, E. De Lorenzis, R. L. Ross, J. Bryon, E. Derrett-Smith, C. P. Denton, P. J. Meakin, F. Del Galdo
This study shows CLIC4 regulates type 1 interferon signaling in SSc epithelial cells and inhibiting it blocks IFN pathway activation.
bioRxiv · Mar 8, 2024 · PreprintImmunology