Author

E. M. Clavane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. J. Meakin· 3 shared C. W. Wasson· 2 shared E. De Lorenzis· 2 shared F. Del Galdo· 2 shared R. L. Ross· 2 shared R. Wells· 2 shared B. Caballero Ruiz· 1 shared B. Caballero-Ruiz· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

P. J. Meakin

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Author profile →

3 papers

Recent·Most cited

Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

C. G. Myers, H. Viswambharan, N. Haywood, K. Bridge, S. J. Turvey, T. Armstrong, L. Lunn, P. J. Meakin, E. M. Clavane, D. J. Beech, R. M. Cubbon, S. B. Wheatcroft, M. J. McPhillie, T. Issad, C. W. Fishwick, , K. J. Simmons

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

bioRxiv · Mar 11, 2024Cell Biology

Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells

C. W. Wasson, S. L. Dibb, B. Caballero Ruiz, E. M. Clavane, R. Wells, V. Kakkar, E. De Lorenzis, R. L. Ross, J. Bryon, E. Derrett-Smith, C. P. Denton, P. J. Meakin, F. Del Galdo

This study shows CLIC4 regulates type 1 interferon signaling in SSc epithelial cells and inhibiting it blocks IFN pathway activation.

bioRxiv · Mar 8, 2024 · PreprintImmunology

The Beta secretase BACE1 drives fibroblasts activation in Systemic Sclerosis through the APP/Beta-catenin/Notch signalling axis

C. W. Wasson, E. De Lorenzis, E. M. Clavane, R. L. Ross, K. A. Walker, B. Caballero-Ruiz, C. Antinozzi, R. Wells, G. Migneco, J. M. Y. Brown, N. A. Riobo-Del Galdo, L. Di Luigi, C. S. McKimmie, F. Del Galdo, P. J. Meakin

This study shows BACE1 drives fibroblast activation in systemic sclerosis via the APP/Beta-catenin/Notch axis and identifies BACE1 as a potential therapeutic target.

bioRxiv · Dec 22, 2022Immunology