Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations in vivo
Y.-T. Liu, X. Huang, D. Nguyen, E. Dombi, D. A. Springer, J. Poulton, S. Sekine, D. P. Narendra
This study shows that loss of CHCHD2 and CHCHD10 activates OMA1, leading to mitochondrial cristae disruption similar to patient mutations, linking C10 pathogenesis to C2/C10 function.
bioRxiv · Sep 18, 2019Cell Biology