S. Sekine

A mitochondrial iron-sensing pathway regulated by DELE1

This study identifies DELE1 as a mitochondrial protein whose import and stability are regulated by iron availability, linking mitochondrial function to the heme-regulated kinase HRI-mediated stress response.

Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data

This paper predicts chemical toxicities using induced pluripotent stem cells and gene networks via transfer learning from embryonic stem cell data, achieving high accuracy across multiple toxicity categories.

Discovery of bactericides as an acute mitochondrial membrane damage inducer

The paper identifies Chlorhexidine and Alexidine as bactericides that induce acute mitochondrial membrane damage by altering inner mitochondrial membrane integrity and evoking a unique stress response.

Acetylation-mediated phase control of the nucleolus regulates cellular acetyl-CoA responses

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations in vivo

This study shows that loss of CHCHD2 and CHCHD10 activates OMA1, leading to mitochondrial cristae disruption similar to patient mutations, linking C10 pathogenesis to C2/C10 function.

Improved Split Fluorescent Proteins For Endogenous Protein Labeling

The paper develops improved split fluorescent proteins for endogenous protein labeling, showing enhanced signal-to-background ratios and new applications in super-resolution microscopy.