Tumor Immune Cell Targeting Chimeras (TICTACs) reprogram tumor-associated macrophages
M. Morimoto, D. S. Roberts, R. Wen, E. Handy, E. E. Peterson, G. M. Stepek, N. A. Till, J. D. Brooks, C. R. Bertozzi
The paper develops TICTACs, which selectively target and degrade checkpoint receptors on tumor-associated macrophages without affecting other cells.
bioRxiv · Dec 6, 2023 · PreprintBiochemistry