Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies
C. Cherry, J. I. Andorko, K. Krishnan, J. C. Mejias, H. H. Nguyen, K. B. Stivers, E. F. Gray-Gaillard, A. Ruta, N. Hamada, M. Hamada, I. Sturmlechner, S. Trewartha, J. H. Michel, L. D. Huyer, M. T. Wolf, , J. H. Elisseeff
The paper develops a transfer learning approach to identify senescent cells across species and tissues using an in vivo-derived gene expression signature, revealing conserved and tissue-specific senescence features.
bioRxiv · Mar 22, 2022 · PreprintBioengineering