K. Krishnan

Control of wildtype zebrafish optomotor response with a photoswitchable drug

This study uses Carbadiazocine to modulate optomotor responses in zebrafish larvae, showing reduced accuracy and altered movement patterns when activated by light.

Probing Conformational Landscapes and Mechanisms of Allosteric Communication in the Functional States of the ABL Kinase Domain Using Multiscale Simulations and Network-Based Mutational Profiling of Allosteric Residue Potentials

This study uses multiscale simulations and network-based mutational profiling to analyze conformational dynamics and allosteric communication in the ABL kinase domain, identifying key regulatory hotspots.

Atomistic Simulations and Network-Based Energetic Profiling of Binding and Allostery in the SARS-CoV-2 Spike Omicron BA.1, BA.1.1, BA.2 and BA.3 Subvariant Complexes with the Host Receptor: Revealing Hidden Functional Roles of the Binding Hotspots in Mediating Epistatic Effects and Long-Range Communication with Allosteric Pockets

This study uses atomistic simulations and network analysis to quantify binding energy hotspots and epistatic effects in Omicron subvariant RBD-ACE2 complexes.

The role of wingbeat frequency and amplitude in flight power

The paper examines how wingbeat frequency and amplitude relate to flight power in birds, finding that amplitude is more variable and better reflects energy demands than frequency alone.

Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms

This study integrates conformational dynamics and perturbation-based network modeling to analyze mutational escape mechanisms in SARS-CoV-2 spike variants bound to antibodies.

Helminth egg derivatives as pro-regenerative immunotherapies

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

Hierarchical Computational Modeling and Dynamic Network Analysis of Allosteric Regulation in the SARS-CoV-2 Spike Omicron Trimer Structures: Omicron Mutations Cooperate to Allosterically Control Balance of Protein Stability and Conformational Adaptability

This study uses computational modeling to analyze how Omicron mutations in the SARS-CoV-2 spike protein regulate structural stability and conformational adaptability through allosteric networks.

Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies

The paper develops a transfer learning approach to identify senescent cells across species and tissues using an in vivo-derived gene expression signature, revealing conserved and tissue-specific senescence features.

The Landscape-Based Protein Stability Analysis and Network Modeling of Multiple Conformational States of the SARS-CoV-2 Spike D614 Mutant: Conformational Plasticity and Frustration-Driven Allostery as Energetic Drivers of Highly Transmissible Spike Variant

This study analyzes the conformational dynamics and mutational sensitivity of the SARS-CoV-2 D614G spike mutant using simulations and network analysis, finding increased conformational adaptability and allosteric regulation.

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

This study identifies two fatty acid binding sites in ELIC and shows that DHA selectively inhibits the channel by binding to a specific site in the agonist-bound state.

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

Key kinematic features in early training predict performance of adult female mice in a single pellet reaching and grasping task

The paper identifies kinematic features from mouse reaching tasks that predict motor performance and efficiency in adult mice.

Systematic analysis of goal-related movement sequences during maternal behavior in a female mouse model for Rett syndrome

The paper systematically analyzes pup retrieval behavior in female mice with and without Rett syndrome, identifying atypical tactile interactions and dynamic movement sequences in the disorder model.

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

This study identifies how neurosteroids interact with three distinct sites on the GABAA receptor, influencing activation and desensitization, and shows that site-specific binding determines their functional effects.

Hydrodynamic regime drives flow reversals in suction feeding larval fishes during early ontogeny

This study investigates how hydrodynamic regimes affect prey transport in larval fish, finding that flow reversals at the mouth orifice can prevent successful suction feeding.