J. H. Elisseeff

Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Helminth egg derivatives as pro-regenerative immunotherapies

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

Transfer learning of an in vivo-derived senescence signature identifies conserved and tissue-specific senescence across species and diverse pathologies

The paper develops a transfer learning approach to identify senescent cells across species and tissues using an in vivo-derived gene expression signature, revealing conserved and tissue-specific senescence features.

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

Biomaterials direct functional B cell response in a material specific manner

This study shows that biomaterial composition influences B cell responses, with ECM materials inducing plasmablasts and antigen presentation, while synthetic PCL delays B cell migration and induces antigen-presenting phenotypes.

Single cell RNA-seq in regenerative and fibrotic biomaterial environments defines new macrophage subsets

The paper uses single-cell RNA sequencing to identify distinct macrophage subsets in regenerative and fibrotic environments, revealing new phenotypes and potential therapeutic targets.